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The Ghana Health Service (GHS) is a Ghanaian government body, established under Act 525 of 1996, as required by the 1992 Constitution as part of the Health Sector Reform of Ghana. The Health Service is under the Ministry of Health. The GHS is therefore a Public Service body. It is an autonomous Executive Agency responsible for the implementation of national policies under the control of the Minister for Health through its governing council, the Ghana Health Service Council.

The Health Service primarily administers the health services provided by the government and implements government policies on healthcare. It's mandate is to provide and prudently manage comprehensive and accessible health services with special emphasis on primary health care at regional, district and sub-district levels, in accordance with approved national policies. The vision is that all communities have access to timely, quality, and comprehensive health care.

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The Kintampo Health Research Centre (KHRC), established in 1994 in Ghana's Bono East Region, is a leading public health research institution under the Ghana Health Service. It conducts high-quality research in areas such as maternal and child health, infectious and non-communicable diseases, and environmental health. KHRC is known for its large demographic surveillance system and contributes to health policy, training, and global health initiatives through national and international partnerships.